VTE has a combined annual incidence of 1–2 events per 1,000 population in the United States. However, venous thromboembolism (VTE), including lower- and upper-extremity deep-vein thrombosis (DVT) and pulmonary embolism (PE), represents a major complication of this surgery. Total joint arthroplasty is generally regarded as a highly successful surgical intervention. Zhu.Ĭompeting interests: NO authors have competing interests. Zhu, The Youth Science Foundation of Xiangya Hospital (2019Q19) to JX.
Zhu, the National Natural Science Fundation of Hunan Province, China (2020JJ5958) to JX. The work is made available under the Creative Commons CC0 public domain dedication.ĭata Availability: All relevant data are within the manuscript and its Supporting information files.įunding: This study was funded by the National Natural Science Fundation of China (82002373) to JX.
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Received: DecemAccepted: MaPublished: June 17, 2021 PLoS ONE 16(6):Įditor: Yoshihiro Fukumoto, Kurume University School of Medicine, JAPAN No statistically significant heterogeneity was observed between trials.Ĭitation: He T, Han F, Wang J, Hu Y, Zhu J (2021) Efficacy and safety of anticoagulants for postoperative thrombophylaxis in total hip and knee arthroplasty: A PRISMA-compliant Bayesian network meta-analysis. Thus, the selection of studies for systematic review is to be done carefully to obtain significant results.Thirty-five RCTs (53787 patients mean age range, mostly 55–70 years mean weight range, mostly 55–90 kg and a higher mean proportion of women than men, around 60%) included the following Anticoagulants categories: fondaparinux, edoxaban, rivaroxaban, apixaban, dabigatran, low-molecular-weight heparin, ximelagatran, aspirin, warfarin. The high degree of heterogeneity and interstudy variance produced insignificant summary effect estimate.
The plausible explanation for the same is that the studies in event rates data were highly heterogeneous. On one hand, the event rate data did not yield significant association, whereas odds ratio analysis result was opposite. The investigation into the association of gallstones with gallbladder carcinoma via the different set of studies reports different results. The illustration of different procedures via different data type and studies highlights the significance of study selection. Visualization, customization, and interpretation of results.Performing meta-analysis for Events rate and Odds ratio data.
Data entry – Manual and Import procedures.
The article series beginning from Performing manual data entry in CMA spreadsheet up till now elaborates the following: Image 8: Intercept test statistics Cancer risk associated with cholecystitis Also, the p-value > 0.05, which indicates the presence of significant asymmetry and bias. The regression test results indicate significant deviation from zero and pronounced the asymmetry. Image 7: Rank correlation test statistics The summary effect size for the random model is 5.376 (95% CI = 2.28-12.65) with p-value = 0.00 (0.05 thereby indicating the acceptance of null hypothesis and the presence of bias. Image 1: Basic summary statistic results Interpretation of summary statistics Also, as the studies do not follow identical research design, hence random effect model selection ensues. The random effects model takes into account both the interstudy variance and sample size, resulting in well-distributed weight. As seen the relative weighting of studies in the two models are quite different. The image below shows the result for meta-analysis of the odds ratio data, for both random and fixed effects model. Results can be obtained by clicking on “Run Analysis”. Yashika Kapoor and Priya Chetty on December 25, 2017